Thank goodness that we have researchers interested in lyme and its myriad of co infecting agents, many of which lead to chronic infection. I would love to see research on how Borrelia affects both cellular as well as humoral immunity and specifically what we can do to restore the immune system. Because of the immune compromising ability of these pathogens, lyme patients show up with reactivated herpes viruses and other opportunistic infections, pretty much the same as in AIDS patients. NON HIV AIDS patients in Asia were shown to have auto antibodies to interferon gamma.

It is very important to understand how the Lyme disease bacteria manages to evade and adapt to the immune response and survive. What we can learn about immunosuppression can help us understand how so many other illnesses can survive and become chronic. This could also relate to it's ability to survive short term antibiotic treatment.